Changes in Inflammatory Markers during Pulmonary Rehabilitation based on Exacerbation Status (CIMPRES)

This CIMPRES project has been ethically approved (REC,HRA & University) and will contribute towards the requirements for a PhD. Alex Jenkins will lead on this project. This project aims to a create further understanding of the importance of pulmonary rehabilitation at both a cellular level and community level following the unique direction outlined by the Lincoln Institute for Health.

The benefits of pulmonary rehabilitation are well known, however there is a scarcity of research looking into how pulmonary rehabilitation affects the immune system. COPD is characterised by a state of persistent inflammation, and in healthy individuals, exercise has been shown to ‘dampen’ inflammation. The transferability of this to COPD is currently not known.

Further to this, the effects of exercise across different phenotypes will also be monitored. We want to see whether frequent exacerbators (2 or more exacerbations in the past 12 months) respond to exercise differently, in terms of inflammatory response and routine clinical outcomes, compared to infrequent exacerbators.

Data collection is now underway with completion set for August 2018 with manuscript submission prepared for October 2018. If you would like to discuss this project further we will be happy to hear from you.


                                                                  COPD Treatment Value                                                                                                                                         COPD Treatment Actual Spend

COPD treatment value pyramidCOPD actual spend pyramid